Publications

2016

Abedalthagafi MS, Wu MP, Merrill PH, Du Z, Woo T, Sheu SH, Hurwitz S, Ligon KL, Santagata S . Decreased FOXJ1 expression and its ciliogenesis programme in aggressive ependymoma and choroid plexus tumours. J Pathol. 2016 Mar;238(4):584-97
Abedalthagafi M, Bi WL, Aizer AA, Merrill PH, Brewster R, Agarwalla PK, Listewnik ML, Dias-Santagata D, Thorner AR, Van Hummelen P, Brastianos PK, Reardon DA, Wen PY, Al-Mefty O, Ramkissoon SH, Folkerth RD, Ligon KL, Ligon AH, Alexander BM*, Dunn IF*, Beroukhim R*, Santagata S*. Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma. Neuro Oncol. 2016 Jan 28.

2015

Brastianos PK, Shankar GM, Gill CM, Taylor-Weiner A, Nayyar N, Panka DJ, Sullivan RJ, Frederick DT, Abedalthagafi M, Jones PS, Dunn IF, Nahed BV, Romero JM, Louis DN, Getz G, Cahill DP*, Santagata S*, Curry WT Jr*, Barker FG 2nd*. Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy. J Natl Cancer Inst. 2015 Oct 23;108(2)
Tsvetkov P, Mendillo ML, Zhao J, Carette JE, Merrill PH, Cikes D, Varadarajan M, van Diemen FR, Penninger JM, Goldberg AL, Brummelkamp TR, Santagata S*, Lindquist S*. Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome. Elife. 2015 Sep 1;4.
Aizer AA, Abedalthagafi M, Bi WL, Horvath MC, Arvold NA, Al-Mefty O, Lee EQ, Nayak L, Rinne ML, Norden AD, Reardon DA, Wen PY, Ligon KL, Ligon AH, Beroukhim R*, Dunn IF*, Santagata S*, and Alexander BM*. A prognostic cytogenetic scoring system to guide the adjuvant management of patients with atypical meningioma. Neuro-oncology, 2015 Aug 30.
Abedalthagafi MS, Bi WL, Merrill PH, Gibson WJ, Rose MF, Du Z, Francis JM, Du R, Dunn IF, Ligon AH, Beroukhim R, Santagata S. ARID1A and TERT promoter mutations in dedifferentiated meningioma. Cancer Genet. 2015 Jun;208(6):345-50.
Brastianos PK*, Carter SL*, Santagata S, Cahill DP, Taylor-Weiner A, Jones RT, Van Allen EM, Lawrence MS, Horowitz PM, Cibulskis K, Ligon KL, Tabernero J, Seoane J, Martinez-Saez E, Curry WT, Dunn IF, Paek SH, Park SH, McKenna A, Chevalier A, Rosenberg M, Barker FG 2nd, Gill CM, Van Hummelen P, Thorner AR, Johnson BE, Hoang MP, Choueiri TK, Signoretti S, Sougnez C, Rabin MS, Lin NU, Winer EP, Stemmer-Rachamimov A, Meyerson M, Garraway L, Gabriel S, Lander ES, Beroukhim R, Batchelor TT, Baselga J, Louis DN, Getz G, Hahn WC. Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. Cancer Discov. 2015 Sep 26.
Du Z, Abedalthagafi M, Aizer AA, McHenry AR, Sun HH, Bray MA, Viramontes O, Machaidze R, Brastianos PK, Reardon DA, Dunn IF, Freeman GJ, Ligon KL, Carpenter AE, Alexander BM, Agar NY, Rodig SJ, Bradshaw EM, Santagata S. Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma. Oncotarget. 2015 Mar 10;6(7):4704-16.
Calligaris D, Feldman DR, Norton I, Olubiyi O, Changelian AN, Machaidze R, Vestal ML, Laws ER, Dunn IF, Santagata S, Agar NYR. MALDI Mass Spectrometry Imaging Analysis of Pituitary Adenomas: Toward the Near Real-Time Delineation of Pituitary Tumors. Proc Natl Acad Sci U S A., 2015 Aug 11;112(32):9978-83.

2014

Lee EQ, Ruland S, LeBoeuf NR, Wen PY, and Santagata S. Successful treatment of a progressive BRAF V600E-mutated anaplastic pleomorphic xanthroastrocytoma with vemurafenib monotherapy. J Clin Oncol. 2014 Aug 4. pii: JCO.
Scherz-Shouval R, Santagata S, Mendillo ML, Sholl LM, Ben-Aharon I, Beck AH, Dias-Santagta D, Montaser-Koushari L, Koeva M, Stemmer SM, Whitesell L, Lindquist L. The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy. Cell 2014 Jul 31;158(3):564-78.
Santagata S*, Eberlin LS*, Norton I, Calligaris D, Feldman DR, Ide JL, Liu XH, Wiley JS, Vestal ML, Ramkissoon S, Orringer D, Gill KK, Dunn IF, Dias-Santagata D, Ligon KL, Joles FA, Golby AJ, Cooks RG, Agar NYR. Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery. Proc Natl Acad Sci U S A., Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11121-6. *Equal Contribution.
Aizer AA, Arvold ND, Catalano P, Claus EB, Golby AJ, Johnson MD, Al-Mefty O, Wen PY, Reardon DA, Lee EQ, Nayak L, Rinne ML, Beroukhim R, Weiss SE, Ramkissoon SH, Abedalthagafi M, ,Santagata S, Dunn IF, Alexander BM. Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma. Neuro Oncol. 2014 Jun 2.
Wen PY, Chang SM, Lamborn KR, Kuhn JG, Norden AD, Cloughesy TF, Robins HI, Lieberman FS, Gilbert MR, Mehta MP, Drappatz J, Groves MD, Santagata S, Ligon AH, Yung WK, Wright JJ, Dancey J, Aldape KD, Prados MD, Ligon KL. Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02. Neuro Oncol. 2014 Apr;16(4):567-78.
Wijeratne EM, Xu YM, Scherz-Shouval R, Marron MT, Rocha DD, Liu MX, Costa-Lotufo LV, Santagata S, Lindquist S, Whitesell L, Gunatilaka AA. Structure-Activity Relationships for Withanolides as Inducers of the Cellular Heat-Shock Response. J Med Chem. 2014 Mar 25.
Filone CM, Caballero Is, Dower K, Mendillo M, Cowley GS, Santagata S, Rozelle D, Yen J, Rubins K, Hacohen N, Root DE, Hensley L, Connor J. The master regulator of the cellular stress response (HSF1) is critical for Orthopoxvirus infection. PLoS Pathog., 2014 Feb 6;10(2):e1003904.
Santagata S, Thakkar A, Ergonul A, Wang B, Woo T, Hu R, Harrell JC, McNamara G, Schwede M, Culhane AC, Kindelberger D, Rodig S, Richardson A, Schnitt SJ, Tamimi RM and Ince TA. Taxonomy of Breast Cancers Based on Normal Cell Phenotype. J Clin Invest. 2014 Feb 3;124(2):859-70.
Brastianos PK, Taylor-Weiner A, Manley PE, Jones RT, Dias-Santagata D, Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L, Sunkavalli A, Shillingford N, Calicchio ML, Lidov HG, Taha H, Martinez-Lage M, Santi M, Storm PB, Lee JY, Palmer JN, Adappa ND, Scott RM, Dunn IF, Laws ER Jr, Stewart C, Ligon KL, Hoang MP, Van Hummelen P, Hahn WC, Louis DN, Resnick AC, Kieran MW, Getz G, Santagata S. Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet. 2014 Feb;46(2):161-5.
Brastianos PK*, Horowitz PM*, Santagata S, Jones RT, McKenna A, Getz G, Ligon KL, Palescandolo E, Van Hummelen P, Ducar MD, Raza A, Sunkavalli A, MacConaill LE, Stemmer-Rachamimov AO, Louis DN, Hahn WC, Dunn IF, Beroukhim R. Genomic sequencing of meningiomas reveals oncogenic SMO and AKT1 mutations. Nat Genet., 2014, Jan 20. *Equal Contribution.
Auclair JR, Salisbury JP, Johnson JL, Petsko GA, Ringe D, Bosco DA, Agar NY, Santagata S, Durham HD, Agar JN. Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation. Proteomics. 2014 May;14(10):1152-7
Abedalthagafi MS, Merrill PH, Linda Bi W, Jones RT, Listewnik ML, Ramkissoon SH, Thorner AR, Dunn IF, Beroukhim R, Alexander BM, Brastianos PK, Francis JM, Folkerth RD, Ligon KL, Van Hummelen P, Ligon AH, Santagata S. Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5 Oncotarget. 2014 Nov 15;5(21):10596-606.
Whitesell L, Santagata S, Mendillo ML, Lin NU, Proia DA and Lindquist S. HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18297-302.

2013

Calligaris D, Norton I, Feldman DR, Ide JL, Dunn IF, Eberlin LS, Cooks RG, Jolesz FA, Golby AJ, Santagata S, Agar NY. Mass spectrometry imaging as a tool for surgical decision-making. Mass Spectrom. 2013 Nov;48(11):i. doi: 10.1002/jms.3194.
Liu X, Ide JL, Norton I, Marchionni MA, Ebling MC, Wang LY, Davis E, Sauvageot CM, Kesari S, Kellersberger KA, Easterling ML, Santagata S, Stuart DD, Alberta J, Agar JN, Stiles CD, Agar NY. Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging. Sci Rep. 2013 Oct 4;3:2859.
Ji M, Orringer DA, Freudiger CW, Ramkissoon S, Liu X, Lau D, Golby AJ, Norton I, Hayashi M, Agar NY, Young GS, Spino C, Santagata S, Camelo-Piragua S, Ligon KL, Sagher O, Xie XS. Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. Sci Transl Med. 2013 Sep 4;5(201):201ra119
Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA Jr, Whitesell L, Lindquist S. Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science. 2013 Jul 19;341(6143):1238303.
Taipale M, Krykbaeva I, Whitesell L, Santagata S, Zhang J, Liu Q, Gray NS, Lindquist S. Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells. Nat Biotechnol. 2013 Jul;31(7):630-7.
Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, Macconaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8188-93.
Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8188-93.
Silverman MA, Misasi J, Smole S, Feldman H, Cohen AB, Santagata S, McManus M and Ahmed AA. Pediatric eastern equine encephalitis: A 40-year Case Series. Emerg Infect Dis. 2013 Feb;19(2):194-201.
Eberlin LS, Norton I, Orringer D, Dunn IF, Liu X, Ide JL, Jarmusch AK, Ligon KL, Jolesz FA, Golby AJ, Santagata S, Agar NY, Cooks RG. Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors. Proc Natl Acad Sci U S A. 2013 Jan 8.

2012

Dai C*, Santagata S*, Tang Z, Shi J, Cao J, Kwon H, Bronson RT, Whitesell L, Lindquist S. Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest. 2012 Sep 4. *Equal Contribution.
Mendillo ML*, Santagata S*, Koeva M, Hu R, Tamimi RM, Fraenkel E, Ince TA, Whitesell L, Lindquist S. HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell 2012 Aug 3;150:549–562. *Equal Contribution.
Craig JM, Vena N, Ramkissoon S, Idbaih A, Fouse SD, Ozek M, Sav A, Hill DA, Margraf LR, Eberhart CG, Kieran MW, Norden AD, Wen PY, Loda M, Santagata S, Ligon KL, Ligon AH. DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues. PLoS One. 2012;7(6):e38881. Epub 2012 Jun 15.
Santagata S, Xu YM, Wijeratne EMK, Kontnik R, Rooney C, Perley CC, Kwon H, Clardy J, Kesari S, Whitesell L, Lindquist S, Gunatilaka AA. Using the heat-shock response to discover anticancer compounds that target protein homeostasis. ACS Chem Biol. 2012 Feb 17;7(2):340-9.
Eberlin LS, Norton I, Dill AL, Golby AJ, Ligon KL, Santagata S, Cooks RG, Agar NY. Classifying human brain tumors using lipid imaging by mass spectrometry. Cancer Res. 2012 Feb 1;72(3):645-54. Epub 2011 Dec 2.

2011

Eberlin LS, Liu X, Ferreira CR, Santagata S, Agar NY, Cooks RG. DESI then MALDI mass spectrometry imaging of lipid and protein distributions in single tissue sections. Anal Chem. 2011 Nov 15;83(22):8366-71.
Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RL, Lindquist S, Ince TA. High levels of nuclear heat shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci USA 2011 Nov 8;108(45):18378-83.
Tian Y, Rich BE, Vena N, Craig JM, Macconaill LE, Rajaram V, Goldman S, Taha H, Mahmoud M, Ozek M, Sav A, Longtine JA, Lindeman NI, Garraway LA, Ligon AH, Stiles CD, Santagata S, Chan JA, Kieran MW, Ligon KL. Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas. J Mol Diagn. 2011 Nov;13(6):669-77.
Cho JY, Tsherniak A, Tamayo P, Santagata S, Ligon A, Greulich H, Lu J, Berhoukim R, Getz G, Amani V, Goumnerova L, Eberhart GC, Lau CC, Olson JM, Gilbertson RJ, Gajjar A, Haberler C, Delattre O, Kool M, Ligon K, Meyerson M, Mesirov JP, and Pomeroy SL. Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome. J Clin Oncol. 2011 Apr 10;29(11):1424-30.
Dias-Santagata D, Lam Q, Vernovsky K, Vena N, Lennerz JK, Borger DR, Batchelor TT, Ligon KL, Iafrate AJ, Ligon AH, Louis DN, Santagata S. BRAF V600E mutations are common in Pleomorphic Xanthoastrocytoma: diagnostic and therapeutic implications. PLoS One. 2011 Mar 29;6(3):e17948.
Milbury CA, Chen CC, Mamon H, Liu P, Santagata S, Makrigiorgos GM. Multiplex Amplification Coupled with COLD-PCR and High Resolution Melting Enables Identification of Low-Abundance Mutations in Cancer Samples with Low DNA Content. J Mol Diagn. 2011 Mar;13(2):220-32.

Before 2011

McMillan, HJ, Santagata S, Shapiro F, Batish SD, Couchon L, Donnelly S, Kang PB. Novel MPZ mutations and congenital hypomyelinating neuropathy. Neuromuscul Disord. 2010 Nov; 20(11):725-9.
Haskew-Layton RE, Payappilly JB, Smirnova NA, Ma TC, Chan KK, Murphy TH, Guo H, Langley B, Sultana R, Butterfield DA, Santagata S, Alldred MJ, Gazaryan IG, Bell GW, Ginsberg SD, Ratan RR. Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17385-90.
Lengner CJ , Gimelbrant AA, Erwin, JA Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, Jaenisch R, Mitalpova M. Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations. Cell. 2010 May 28;141(5):872-83.
McIntire MG, Santagata S, Ligon K, Chirieac LR. Epidermal growth factor receptor gene amplification in atypical adenomatous hyperplasia of the lung. Am J Transl Res. 2010 May 16;2(3):309-15.
Santagata S, Maire C, Idbaih A, Geffers L, Correll M, Holton K, Quackenbush J, and Ligon KL. CRX is A Diagnostic Marker of Retinal and Pineal Lineage Tumors. PLoS One. 2009 Nov 20;4(11):e7932.
Macconaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasani R, Kieran MW, Ligon KL, Stiles CD, Hahn WC, Meyerson ML, Garraway LA. Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples. PLoS One. 2009 Nov 18;4(11):e7887.
Kritzer JA, Hamamichi S, McCaffery JM, Santagata S, Naumann TA, Caldwell KA, Caldwell GA and Lindquist S. Rapid Selection of Cyclic Peptides that Reduce Alpha-Synuclein Toxicity in Yeast and Animal Models. Nat Chem Biol. 2009 Sep;5(9):655-63.
Kesari S, Schiff D, Drappatz J, Lafrankie D, Doherty L, Macklin EA, Muzikansky A, Santagata S, Ligon KL, Norden AD, Ciampa A, Bradshaw J, Levy B, Radakovic G, Ramakrishna N, Black PM, Wen PY. Phase II Study of Protracted Daily Temozolomide for Low-Grade Gliomas in Adults. Clin Cancer Res. 2009 Jan 1;15(1):330-337.
Santagata S, Ligon KL Hornick JL. Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors. Am J Surg Pathol. 2007 Jun;31(6):836-845.
Santagata S, Hornick JL and Ligon KL. Comparative analysis of germ cell transcription factors In CNS germinoma reveals diagnostic utility of Nanog. Am J Surg Pathol. 2006 Dec;30(12):1613-1618.
Dahia PLM, Ross K, Wright ME, Hayashida CY, Santagata S, Barontini M, Kung AL, Sanso G, Powers JA, Tischler A, Hodin R, Heitritter S, Moore Jr. F, Dluhy R, Sosa JA, Ocal IT, Benn DE., Marsh DJ, Robinson BG, Schneider K, Garber J, Arum SM, Korbonits M, Grossman A, Pigny P, Toledo SPA., Nosé V, Li C, Stiles CD. A HIF1regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. 2005; PLoS Genet 2005 Jul;1(1): 73-80.
Santagata S, Demichelis F, Riva A, Varambally S, Hofer MD, Kutok JL, Kim R, Tang J, Montie JE, Chinnaiyan AM, Rubin MA, Aster JC. JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res 2004 Oct 1;64(19):6854-6857.
Santagata S, Boggon TJ, Baird CL, Gomez C, Zhao J, Shan WS, Myszka DG, Shapiro L. G-protein signaling through Tubby proteins. Science 2001 Jun 15;292(5524):2041-50.
Villa A, Sobacchi C, Notarangelo LD, Bozzi F, Abinun M, Abrahamsen TG, Arkwright PD, Baniyash M, Brooks EG, Conley ME, Cortes P, Duse M, Fasth A, Filipovich AM, Infante AJ, Jones A, Mazzolari E, Muller SM, Pasic S, Rechavi G, Sacco MG, Santagata S, Schroeder ML, Seger R, Strina D, Ugazio A, Valiaho J, Vihinen M, Vogler LB, Ochs H, Vezzoni P, Friedrich W, Schwarz K. V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations. Blood 2001 Jan 1;97(1):81-88.
Santagata S*, Gomez CA, Sobacchi C, Bozzi F, Abinun M, Pasic S, Cortes P, Vezzoni P, Villa A. N-terminal RAG1 frameshift mutations in Omenn’s syndrome: Internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains. Proc Natl Acad Sci USA 2000 Dec 19;97(26):14572-14577. * Corresponding author
Gomez CA, Ptaszek LM, Villa A, Bozzi F, Sobacchi C, Brooks EG, Notarangelo LD, Spanopoulou E, Pan ZQ, Vezzoni P, Cortes P, Santagata S*. Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies. Mol Cell Biol 2000 Aug;20(15):5653-64. * Corresponding author
Aidinis V, Dias DC, Gomez CA, Bhattacharyya D, Spanopoulou E, Santagata S*. Definition of minimal domains of interaction within the Recombination-Activating Genes 1 and 2 Recombinase Complex. J Immunol 2000 Jun 1;164(11):5826-5832. * Corresponding author
Boggon TJ, Shan WS, Santagata S, Myers SC, and Shapiro L. Implication of Tubby proteins as transcription factors by structure-based functional analysis. Science 1999 Dec10;286 (5447):2119-25.
Santagata S, Besmer E, Villa A, Bozzi F, Allingham JS, Sobacchi C, Haniford DB, Vezzoni P, Nussenzweig MC, Pan ZQ, Cortes P. The RAG1/RAG2 complex constitutes a 3′ flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination. Mol Cell 1999 Dec;4(6):935-47.
Aidinis V, Bonaldi T, Beltrame M, Santagata S, Bianchi ME, Spanopoulou E. The RAG1 Homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2. Mol Cell Biol 1999 Oct;19(10):6532-6542.
Santagata S, Bhattacharya D, Wang FH, Singha N, Hodtsev A and Spanopoulou E. Molecular cloning and characterization of a mouse homolog of bacterial ClpX, a novel mammalian class II member of the Hsp100/Clp chaperone family. J Biol Chem 1999 Jun 4;274(23):16311-16319.
Santagata S, Aidinis V, Spanopoulou E. The effect of Me2+ cofactors at the initial stages of V(D)J recombination. J Biol Chem 1998 Jun 26;273(26):16325-16331.
Villa A, Santagata S, Bozzi F, Giliani S, Frattini A, Imberti L, Gatta LB, Ochs HD, Schwarz K, Notarangelo LD, Vezzoni P, Spanopoulou E. Partial V(D)J recombination activity leads to Omenn syndrome. Cell 1998 May 29;93(5):885-896.
Spanopoulou E, Zaitseva F, Wang FH, Santagata S, Baltimore D, Panayotou G. The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination. Cell 1996 Oct 18;87(2):263-276.

 

 

 

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